Emergex Signs an R&D Agreement with IMCB to Develop a Vaccine for the Emerging Threat of Hand, Foot & Mouth Disease

  • Agreement targets the development of a cross-reactive vaccine to protect against the most virulent enteroviruses, including enterovirus 71 (EV71)
  • EV71 was responsible for recent outbreaks in Asia, resulting in a large number of infant deaths

Oxford, UK – 27 June 2019 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to synthetic vaccine development in the field of infectious diseases, today announced that it has signed an R&D agreement with the Institute of Molecular and Cell Biology (IMCB) in Singapore to develop a fully synthetic vaccine against human viruses that cause Hand, Foot and Mouth Disease (HFMD). Emergex and IMCB will collaborate closely to develop the new vaccine, combining their personnel, specialist knowledge and expertise.

IMCB is a research institute of the Agency for Science, Technology and Research (A*STAR), Singapore’s lead government agency spearheading mission-oriented research to advance scientific discovery and develop innovative technology. A*STAR bridges the gap between academia and industry and, through collaboration, brings science and technology to benefit the economy and society.

Storme Moore-Thornicroft, Co-Founder and COO of Emergex, commented: “We are looking forward to collaborating with IMCB on this important indication. Our novel approach to vaccine development provides a practical and efficient solution to prevent disease. Compared to traditional methods, our technology enables development in a shorter time and at a fraction of the cost. Our vaccines also benefit from microneedle skin patch technology, improving vaccine administration and uptake. Our vaccines are 100% synthetic so do not require refrigeration, enabling easier transportation – especially important in infrastructurally-challenged parts of the world.”

The research collaboration is led by Associate Professor Justin Chu, Joint Principal Investigator at IMCB, whose research interests are in positive-strand RNA viruses and vaccine development.

Prof Hong Wanjin, Executive Director of IMCB, commented: “Over recent years, the virulence of Hand, Foot and Mouth Disease has increased substantially and resulted in a number of infant deaths. An urgent need therefore exists to develop an effective vaccine that can provide a practical solution and protect those most at risk.”

As part of the agreement, Emergex will use its technological expertise to help develop a cross reactive vaccine against the most common enteroviruses known to cause HFMD, including coxsackieviruses and enterovirus 71 (EV71) which will be tested in murine models at IMCB.

HFMD is most common in children under the age of 5. It starts with a fever, sore throat and reduced appetite and leads to painful sores on the hands, feet, and in the mouth. While it usually resolves spontaneously, infection with some enteroviruses such as EV71 can induce diverse neurological complications including brainstem encephalitis. This can cause neurogenic pulmonary hemorrhage/edema and lead to death.

Several large outbreaks of HFMD caused by EV71 have occurred in the Asia-Pacific region since 1997. In 1998, a major epidemic of EV71 in Taiwan caused 1.5 million infections, 405 with severe neurological complications, and 78 child deaths. More than 7 million HFMD cases and 2,457 deaths were reported in China during EV71 epidemics between 2008 and 2012. Recently, EV71 epidemics have been reported in the USA and Europe including the Netherlands, France, Norway, the UK, Hungary, and Greece.

– Ends –

Notes To Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited (“Emergex”), a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats including Flaviviruses, such as Dengue Fever and Zika, as well as Filoviruses, such as Ebola and Marburg viruses, and seasonal and pandemic influenza.

The Company has developed a novel and ground-breaking approach to vaccine manufacturing. It utilises 100% synthetic components that have been validated in previous research, to activate T-cells of the immune system to destroy infected human cells. It uses unique technologies, together with scientific insights to develop and manufacture vaccines at a fraction of the time and cost of conventional vaccines. These are administered using a skin patch technology which is practical to administer and suited for regions that are infrastructurally-challenged as well as for more advanced regions of the world.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Emergex is a member of the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com and connect with us via Twitter @EmergexVaccines.

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp / Genevieve Wilson

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

 

Dr. Athanasios Papadopoulos joins Emergex as Chief Medical Officer

Oxford, UK – 27 February 2019 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to synthetic vaccine development in the field of infectious diseases, today announces the appointment of Athanasios Papadopoulos, MD, as Chief Medical Officer (CMO), effective 1st March 2019. Dr. Papadopoulos will report directly to Emergex’s CEO Professor Thomas Rademacher.

In his new role Dr. Papadopoulos will use his extensive medical, regulatory and clinical development expertise to provide leadership and direction on the development of Emergex’s growing pipeline of vaccines.

Dr. Papadopoulos joins Emergex from Sanofi, the global pharmaceutical company, where he was most recently Associate Vice President, Senior Director and Clinical Franchise Leader of Global Clinical Sciences since 2015. During his time at Sanofi Dr. Papadopoulos played a critical role in the development of Dengvaxia®, the first vaccine approved for Dengue fever.

Prior to joining Sanofi, Dr. Papadopoulos worked at Novartis as Medical Affairs Director and Senior Global Clinical Research Physician as well as Lead Head of CLS and Senior Director of Clinical Development. During his time at Novartis, he contributed to the successful development and approval of the breakthrough Bexsero® Meningitis B vaccine.

Dr. Papadopoulos originally trained as a general practitioner in Greece and specialized as a clinical bio-pathology consultant. He has a wealth of clinical knowledge, strengthened by his more than 20 years of experience working in industry – 10 of which he has spent holding senior life sciences leadership roles.

Dr. Papadopoulos speaks English, French, Italian, Greek and Bulgarian and in his spare time enjoys judo and painting.

Storme Moore-Thornicroft co-founder and COO at Emergex commented, “It is a testament to the quality of our science that someone with Athanasios’ experience has chosen to join our executive management team. His knowledge and experience working in senior positions and the successful development and approval of a number of vaccines makes him the perfect candidate to be our new CMO. We look forward to working with him as our programmes progress into and through clinical development.”

On his appointment as the new CMO, Dr Athanasios Papadopoulos commented, “Coming from a larger, multinational corporation I am eager to explore the opportunities that come with working in a competitive, entrepreneurial, high-growth Company. Emergex’s novel technology and pipeline hold the potential to revolutionise infectious disease prevention and treatment and I am keen to be a part of the team as they strive to realise that vision.”

– Ends –

Notes To Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited (“Emergex”), a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats including Flaviviruses, such as Dengue Fever and Zika as well as Filoviruses, such as Ebola and Marburg viruses, and seasonal and pandemic influenza.

The Company has developed a novel and ground-breaking approach to vaccine manufacturing. It utilises 100% synthetic components that have been validated in previous research, to activate T-cells of the immune system to destroy infected human cells. It uses unique technologies together with scientific insights to develop and manufacture vaccines at a fraction of the time and cost of conventional vaccines. These are administered using a skin patch technology which is practical to administer and suited to regions that are infrastructurally-challenged as well as for more advanced regions of the world.

Emergex is initially focussed on creating an internationally accessible, clinical-grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Emergex is a member of the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.
Find out more online at www.emergexvaccines.com and connect with us via Twitter @EmergexVaccines.

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp / Genevieve Wilson

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

 

Emergex Secures State-of-the-art R&D Facility and Hires a Chief Scientific Officer to Drive Development of its Vaccines

Oxford, UK – 18 February 2019 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a novel approach to the development of vaccines for infectious diseases, today announces that it has successfully secured a state-of-the-art-research and development (R&D) facility at Milton Park, Oxfordshire.

In addition, Emergex is pleased to announce the appointment of Dr. Phillip Williams as Chief Scientific Officer (CSO), who will lead the Company’s R&D operations on site. A nanotechnology expert, Dr. Williams has extensive experience in the field of gold nanoparticle development and has been involved in the production and validation of the world’s first up-scaling methodologies for nanoparticles of this nature. Dr. Williams’ appointment as CSO of Emergex follows his successful term as Principle Scientist at Midatech Pharma.

The Milton Park facility provides Emergex with its own fully equipped and resourced in-house R&D capabilities. This gives the Company overall internal control of all its vaccine development programs. Furthermore, key personnel at the site, who are highly experienced in the design, production and development of nanoparticles, have joined Emergex. This will further enhance the skills and expertise required for Emergex to progress its potentially industry-altering approach to vaccine development.

Storme Moore-Thornicroft, Co-Founder and COO of Emergex commented, “On behalf of the management team, I would like to welcome Phil and our newly appointed team of scientists to Emergex. We are looking forward to working together to effectively progress our vaccine candidates through the development pathway. These appointments, along with securing and further enhancing our own operational capability via this new facility, represent a real and significant milestone in the evolution and growth of our business.”

Dr Phillip Williams, Emergex’s new CSO commented, “It is an exciting time to join Emergex as several of its vaccines advance through preclinical development. As well as being designed to provide long-lasting immunity and to be easily administered, Emergex’s vaccines can be rapidly produced for testing and then cost-effectively manufactured, a great feat in the vaccines industry and one of which I am proud to be a part.”

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited (“Emergex”), a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats including Flaviviruses, such as Dengue Fever and Zika as well as Filoviruses, such as Ebola and Marburg viruses, and seasonal and pandemic influenza.

The Company has developed a novel and ground-breaking approach to vaccine manufacturing. It utilises 100% synthetic components that have been validated in previous research, to activate T-cells of the immune system to destroy infected human cells. It uses unique technologies together with scientific insights to develop and manufacture vaccines at a fraction of the time and cost of conventional vaccines. These are administered using a skin patch technology which is practical to administer and suited to regions that are infrastructurally-challenged as well as for more advanced regions of the world.

Emergex is initially focussed on creating an internationally accessible, clinical-grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Emergex is a member of the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp / Genevieve Wilson

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

Emergex Demonstrates Excellent Safety Profile for Gold Nanoparticle Used in its Vaccine Platform

  • Gold nanoparticle forms the fundamental basis for all of Emergex’s vaccine constructs
  • These toxicology results help pave the way for a Phase I clinical trial in 2019 of Emergex’s first vaccine candidate targeting Flaviviruses

Oxford, UK, 24 October 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to synthetic vaccine development in the field of infectious diseases, today announces the successful completion of preclinical toxicology testing on the gold nanoparticle carrier system that forms the fundamental basis for Emergex’s entire infectious disease vaccine platform.

Toxicology studies complying with good laboratory practice (GLP) were successfully completed in standard industry models using Emergex’s gold nanoparticle at a range of doses. No toxicological effects, as measured by key markers, were detected at any level of dosing, confirming the safety of the gold nanoparticle in these models.

The gold nanoparticle forms the central core (or “scaffold”) for immunogenic peptides that together form the final construct for development. The particles can be made to measure less than 5 nanometers in diameter. They act as the carrier system for immunogenic vaccine constructs that comprise synthetic peptides derived from highly conserved components of the disease-causing virus, microbe or pathogen. These peptides have been reverse-engineered using post-infectious blood to identify and select peptides that elicit the strongest cell-mediated immune response. The excellent safety profile demonstrated in these successful preclinical studies now enables Emergex to progress further toxicology testing on viral vaccine constructs in Emergex’s development pipeline and, provided they are successful, first-in-man Phase I safety studies.

Emergex’s first vaccine candidate is scheduled to enter Phase I clinical testing in 2019. It contains immunogenic peptides that are derived from viruses such as Dengue and Zika within the Flavivirus family. The Flavivirus vaccine is designed to universally target this viral genus.

Due to their small size, Emergex’s vaccines can directly enter immune processing cells and trigger cell-mediated immune responses within infected host cells. The small size also enables administration via microneedle patch technology which is less invasive than conventional needle vaccination. Using this administration method the vaccine enters the dermal level of the skin, which then directly stimulates the immune system. Emergex’s vaccine technology can also be applied for the development of vaccines for other pathogenic microbes such as antibiotic resistant bacteria.

Laurens Rademacher, Emergex’s Chief Technology Officer commented: “These results are a significant milestone as we advance towards clinical development of our Flavivirus vaccine. The excellent safety profile that we have seen on our base gold nanoparticle in these preclinical studies provides us with renewed confidence in a significant part of the contributing technology. We therefore expect the regulatory process for the upcoming clinical phases to be attainable within our anticipated timelines, ensuring that we remain on course to achieve our vision of providing vaccines that are effective, affordable and safe.”

Emergex’s business model is to create International Vaccine Repositories of post Phase I vaccines that act as a first-line of defense against existing, emerging and emergency infectious outbreaks and that will be subscribed to by governments, non-governmental organisations and/or charities. Access to these are repository is expected to provide Emergex with initial revenues.

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited (“Emergex”), a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats including Flaviviruses, such as Dengue Fever and Zika as well as Filoviruses, such as Ebola and Marburg viruses, and seasonal and pandemic influenza.

The Company has developed a novel and ground-breaking approach to vaccine manufacturing. It utilises 100% synthetic components that have been validated in previous research, to activate T-cells of the immune system to destroy infected human cells. It uses unique technologies together with scientific insights to develop and manufacture vaccines at a fraction of the time and cost of conventional vaccines. These are administered using a skin patch technology which is practical to administer and suited to regions that are infrastructurally-challenged as well as for more advanced regions of the world.

Emergex is initially focussed on creating an internationally accessible, clinical-grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Emergex is a member of the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

 

Emergex Enters into MoU with Brazil’s Fiocruz to Develop Novel Vaccines Against Viral Diseases

Oxford, UK, 20 September 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to synthetic vaccine development in the field of infectious diseases, today announces that it has signed a Memorandum of Understanding (MoU) with Brazil-based Oswaldo Cruz Foundation ‘Fiocruz’ for the development of viral vaccines. The MoU initially covers the development of a vaccine that universally targets diseases within the flavivirus family such as Dengue Fever, Zika and Yellow Fever but could be expanded to include the development of vaccines to target other viral families that are endemic to the region.

The MoU consists of three parts. The first part is a Collaboration Agreement under which Fiocruz and Emergex will initially carry out a Phase I clinical trial to demonstrate flavivirus vaccine safety. Thereafter, the two parties expect to carry out further clinical studies to test the vaccine in the field. The second part of the MoU is an ‘umbrella’ R&D agreement under which Emergex and Fiocruz will co-develop vaccines to viruses that are of specific importance to the Brazilian government and are prevalent and endemic in the region. Emergex and Fiocruz will develop vaccines collaboratively to find solutions for various diseases that have not yet been resolved using conventional vaccine approaches. The third part of the MoU covers a vaccine technology transfer agreement for vaccines that will be used within Brazil’s National Health Service.

Emergex’s vaccines are 100% synthetic, multi-component vaccines containing peptides that are highly conserved between viral strains. This means that Emergex can create a “universal” vaccine that is cross-reactive and targets numerous diseases within one viral family. One example of this is Emergex’s universal flavivirus vaccine which is designed to target diseases such as Dengue Fever, Zika and Yellow Fever.

Professor Thomas Rademacher, co-founder, CEO and CSO at Emergex commented: “Fiocruz is recognized as one of the world’s largest public health research institutions. It has a broad range of responsibilities related to the health and wellbeing of the Brazilian population of over 207 million people. The signing of this MoU is a commitment to explore how our organizations can work together to develop new vaccines against major viral threats that occur in the region.”

Marco Krieger, VP Production and Innovation at Fiocruz added: “Fiocruz is committed to researching, developing and manufacturing new vaccines to address Brazil’s most important infectious diseases. This MoU demonstrates our intention to partner with Emergex to develop a new generation of vaccines. We chose Emergex as its technology enables it to develop and manufacture vaccines in less time and at a fraction of the cost of traditional vaccines. Its vaccine components are stable at ambient temperatures, avoiding the need for refrigeration, reducing costs and enabling easy transportation – making it particularly suited to treating diseases in remote parts of the world.”

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited, a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats such as Zika, Ebola, pandemic flu and antibiotic resistant bacteria.

It has developed a novel and ground-breaking approach to vaccine manufacturing, reverse engineering the immune system and providing that system with data that alters the viral factory. It utilises 100% synthetic components that have been validated in previous research, to activate T-cells of the immune system to destroy virus-infected human cells. It uses unique technologies together with cleverly crafted scientific capability to develop and manufacture vaccines at a fraction of the time and cost of conventional vaccines, administered practicably for regions that are infrastructurally-challenged in the developing world as well as for the developed world.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks. It also is strategically open to develop commercially marketed vaccines in partnership with pharmaceutical companies to generate future licensing and royalty revenue streams.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Recently it joined the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

 

About Fundação Oswaldo Cruz (Oswaldo Cruz Foundation, known as Fiocruz)

Inaugurated on May 25, 1900 under the name The Federal SeroTherapy Institute, Fiocruz’s mission was to fight public health problems in Brazil. Since then it has developed and become a leading think tank concerned with Brazilian experimental medicine.

Concepts that have guided Fiocruz’s development include the promotion of health and social development, forging and disseminating scientific and technological knowledge, and promoting the benefits of Brazilian citizenship.

Today, Fiocruz is attached to the Brazilian Ministry of Health and is the most prominent science and technology health institution in Latin America. It is responsible for a range of activities which include research development; highly-regarded hospital and ambulatory care services; production of vaccines, drugs, reagents, and diagnostic kits; education and training of human resources; information and communication in the area of health, science and technology; quality control of products and services, and the implementation of social programs. It has over 7,500 employees and health professionals.

For more information, please visit the Fiocruz website.

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

 

Emergex Appoints US Federal Government Experts The Conafay Group

Oxford, UK, 13 July 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to vaccine development in the field of infectious diseases, today announces that it has appointed The Conafay Group, US Federal Government experts, to advise on the US healthcare landscape and policy and to provide introductions to help establish new business contacts.

Emergex’s business model is initially focused on creating an International Vaccine Repository of post Phase I vaccines, for subscription by governments, non-governmental organisations and charities to act as a first line of defence against existing and newly emerging infectious outbreaks. Emergex’s partnership with The Conafay Group will help them achieve this goal.

The Conafay Group is experienced at providing companies with a unique insights into the US non-dilutive and federal funding landscape, healthcare and innovation policy, federal government needs and priorities, and commercial/institutional partnering opportunities.

Stephen Conafay, founder at Conafay Group commented: “The Conafay Group is proud to partner with Emergex Vaccines to assist in bringing a unique approach to U.S. stakeholders”, said Stephen Conafay, Principal. “By strategically developing a comprehensive approach to engage with the U.S. federal government, we look forward to helping Emergex Vaccines advance solutions through the pipeline and closer to patients around the world.”

Professor Thomas Rademacher, co-founder, CEO and CSO at Emergex commented: “We are looking forward to working closely with The Conafay Group as we continue to progress our vaccines to Phase I. The Conafay Group’s expertise will provide us with new tools and contacts to progress our vision and get our vaccines to patients who really need them.”

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited, a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats such as Zika, Ebola, pandemic flu and antibiotic resistant bacteria.

It has developed a novel and ground-breaking approach to vaccine manufacturing, using 100% synthetic components to activate T-cells of the immune system to destroy virus-infected human cells. It uses unique technologies together with top-notch science to develop and manufacture vaccines much faster and at a fraction of the cost of traditional vaccines.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks. It also plans to develop commercially marketed vaccines in partnership with pharmaceutical companies to generate future licensing and royalty revenue streams.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Recently it joined the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

 

About Conafay Group LLC

The Conafay Group works with life science companies and organizations to develop and implement government funding and public policy strategies.  We also bridge ties to philanthropic, non-profit, academic and commercial entities to enhance client outcomes.  TCG specializes in representing biomedical technologies and therapeutics before the federal government and associated stakeholders. Our client successes involve for-profit and non-profit entities in areas of funding, research and public policy. We identify and target novel funding opportunities, synergies between client technology and federal/private needs, and policy issues that affect life sciences companies. Our expertise provides our clients an advantage over competitors in the federal and non-federal funding market.

Led by Stephen Conafay, The Conafay Group is an assembled team of scientists and policy experts, as well as former industry executives and federal staff, that offers a wealth of scientific and policy expertise in issues relevant to the life sciences and biotechnology industry. Applying this collective expertise, we have an intimate understanding of the non-dilutive funding landscape, healthcare and innovation policy, federal government needs and priorities, and commercial/institutional partnering opportunities. Our strength lies in putting this knowledge, and our familiarity with the science behind our clients’ technology, to work for our clients. Through our team‐based approach, we can deliver fully integrated government relations strategies that enable our clients to achieve greater success.

 

For more information, visit: www.conafaygroup.com

 

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

Emergex Files a Patent in the USA for its novel Pandemic Flu Vaccine

Oxford, UK, 24 May 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to enable synthetic vaccine development in the field of infectious diseases, today announces that it has filed a patent in the USA for its novel pandemic flu vaccine.

The patent, entitled, ‘Reverse Peptide Vaccines’ covers the use of peptides derived from human influenza A, the most frequent influenza serotype and the cause of most major flu outbreaks.

The first recognized flu pandemic was in the summer of 1510 and there have been 15 flu pandemics over the last 500 years1. Following the 1918 Spanish flu and despite the introduction of flu vaccines in the 1940s four further flu pandemics have occurred2. Flu pandemics have always been preceded by flu outbreaks in animals which resulted in the introduction of a viral strain into the human population in which no herd immunity existed and human-to-human transmission was possible. These pandemic characteristics make the use of universal flu vaccines based on current circulating flu strains problematic for the prevention of novel pandemic flu strains entering the human population.

The conserved human HLA-associated peptide fragments covered by this patent are unexpectedly coded by a non-coding strand of RNA conserved in all current human influenza A viruses, including the strain that caused the 1918 ‘Spanish flu’.

As these conserved HLA-associated peptide fragments are present in all human influenza A viruses, it suggests that they play a vital role in human-to-human viral transmission, a key requirement for the establishment of a new flu pandemic derived from circulating animal flu viruses. Mutation of current circulating non-human influenza A viruses and mutations enabling the machinery for the generation of these human HLA-associated peptide fragments could have a serious implication in causing a future human flu pandemic.

Professor Thomas Rademacher, co-founder, CEO and CSO at Emergex commented: “There is an urgent need for novel and innovative solutions that address the threat of a new global flu pandemic. We believe that our synthetic vaccines, combining several cutting-edge technologies could provide a solution.”

Emergex’s synthetic T-cell stimulating influenza vaccines incorporating these human and potentially pandemic-specific targets are currently in pre-clinical testing. On 14 May, Emergex announced that Innovate UK, the UK’s innovation agency, has awarded the company a grant of £979,318 to progress its universal flu vaccine programme through preclinical development.

In addition to developing its flu vaccine, Emergex is also developing a universal Flavivirus vaccine which is cross reactive against Zika, Dengue and Yellow Fever, and a universal Filovirus vaccine which is cross reactive against Ebola and Marburg virus.

References

  1. Pandemic Influenza’s 500th Anniversary. Clinical Infectious Diseases, Volume 51, Issue 12, 15 December 2010, Pages 1442–1444, https://doi.org/10.1086/657429
  2. Influenza Pandemics of the 20th Century. Emerg Infect Dis. 2006 Jan; 12(1): 9–14. doi: https://dx.doi.org/10.3201%2Feid1201.051254

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited, a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats such as Zika, Ebola, pandemic flu and antibiotic resistant bacteria.

It has developed a novel and ground-breaking approach to vaccine manufacturing, using 100% synthetic components to activate T-cells of the immune system to destroy virus-infected human cells. It uses unique technologies together with top-notch science to develop and manufacture vaccines much faster and at a fraction of the cost of traditional vaccines.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks. It also plans to develop commercially marketed vaccines in partnership with pharmaceutical companies to generate future licensing and royalty revenue streams.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Recently it joined the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

 

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

Emergex Awarded Innovate UK Grant to Progress its Universal and Pandemic Flu Vaccine

Oxford, UK, 14 May 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to vaccine development in the field of infectious diseases, today announces that Innovate UK, the UK’s innovation agency, has awarded the company a grant of £979,318 to progress its universal flu vaccine programme through preclinical development.

This grant will cover 70% of the cost of developing Emergex’s flu vaccine programme over a period of two years. It will be used to complete preclinical toxicology and validation studies and the manufacturing of the vaccine in accordance with current Good Manufacturing Practice (cGMP). This will result in clinical batches of the vaccine which are ready for Phase I clinical testing in the first half of 2020.

Emergex’s universal flu vaccine is designed to target components of the influenza virus that are common to all influenza strains. As a result this vaccine will also be suitable to target the outbreak of a new flu pandemic caused by the emergence of a novel form of influenza virus at the time it moves from an animal species into humans. The company’s vaccine is 100% synthetic and delivers highly conserved immunogenic peptide fragments from the flu virus to antigen presenting cells in the skin, eliciting a strong and long-lasting T-cell immune response.

Emergex’s vaccine combines several proprietary technologies to create an immune response based on ‘reverse engineering’. This involves the identification of highly conserved internal peptide fragments from the flu virus, synthesis of these peptide fragments to create a library of 100% synthetic peptide fragments and screening these against blood from flu survivors to see which of the fragments elicit the strongest T-cell immune response. The selected peptide fragments are then combined with a gold nanotechnology carrier system to make an extremely small particle, less than 5 nanometres in diameter, which is ideal for immunization through the skin using a microneedle skin patch, which is less invasive than traditional injection.

The UK government risk register has identified pandemic flu as one of one of the most severe natural challenges likely to affect the UK over the next few years1. A recent World Health Organization model predicts that pandemic flu could kill an estimated 720,000 people per year and result in economic losses of over US$500bn2.

Professor Thomas Rademacher, co-founder, CEO and CSO at Emergex commented, “This Innovate UK grant provides endorsement of our flu vaccine programme and reinforces our belief that an innovative approach, using the very latest technologies, could help protect the public from this inevitable epidemic or pandemic health threat.”

In addition to developing a universal flu vaccine, Emergex is also developing a universal Flavivirus vaccine which is cross reactive against Zika, Dengue and Yellow Fever, and a universal Filovirus vaccine which is cross reactive against Ebola and Marburg virus.

References

  1. UK National Risk Register https://www.scribd.com/document/4746228/UK-National-Risk-Register
  2. How large are the expected losses? Bulletin of the World Health Organization 2018;96:129-134. doi: http://www.who.int/bulletin/volumes/96/2/17-199588/en/

-Ends-

 

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited, a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats such as Zika, Ebola, pandemic flu and antibiotic resistant bacteria.

It has developed a novel and ground-breaking approach to vaccine manufacturing, using 100% synthetic components to activate T-cells of the immune system to destroy virus-infected human cells. It uses unique technologies together with top-notch science to develop and manufacture vaccines much faster and at a fraction of the cost of traditional vaccines.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks. It also plans to develop commercially marketed vaccines in partnership with pharmaceutical companies to generate future licensing and royalty revenue streams.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Recently it joined the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

About Innovate UK

Innovate UK is the UK’s innovation agency. It works with people, companies and partner organisations to find and drive the science and technology innovations that will grow the UK economy. Find out more online at www.innovateuk.gov.uk.

Media Contacts:

Instinctif Partners

Sue Charles / Ashley Tapp

Phone: +44 (0) 20 7457 2020

Email: Emergex@instinctif.com 

Sir David King Joins Emergex’s Board of Directors

Oxford, UK, 29 March 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to vaccine development in the field of infectious diseases, today announces that Sir David King has joined Emergex’s Board as a Non-Executive Director.

David is an Affiliate Partner of SYSTEMIQ, the corporate and government sustainability advisory firm and has held a number of international positions in senior government roles over the last 18 years.

Professor Thomas Rademacher, co-founder, CEO and CSO at Emergex commented, “Our business model is initially focused on creating an International Vaccine Repository of post Phase I vaccines, for subscription by governments, non-governmental organisations and charities to act as a first line of defense against existing and newly emerging infectious outbreaks. Sir David King brings a wealth of international experience and access to government and industry contacts, which will be invaluable to us as we start to commercialise our vaccines.”

Sir David King, Partner of SYSTEMIQ, commented, “When you consider the devastating effects on human health and life caused by disease outbreaks such as Zika, Ebola and Influenza, it becomes obvious that we must do everything we can to combat these infectious diseases. Emergex’s portfolio of vaccines, which are designed to provide long-lasting immunity, to be easily administered as well as rapidly and cost-effectively produced, could have an immense impact worldwide against existing and newly emerging infectious disease outbreaks.”

Most recently, from 2013 – 2017, David was the UK Government Foreign Secretary’s Special Representative on Climate Change, working with 165 Climate Change Attachés in UK Embassies.

From 2012 – 2016 David was the UK Government Chief Scientific Adviser, raising awareness of the need for governments to act on climate change. He was instrumental in creating the Energy Technologies Institute, a public-private partnership between global energy and engineering companies and the UK Government. He also created an in-depth Futures process which advised Government on a wide range of long-term issues, ranging from flooding to obesity.

In addition to his roles in Government, David has also had a distinguished academic career. He attended Witwatersrand University in South Africa, graduating in Chemistry and later obtaining a PhD. David has subsequently received 23 Honorary Degrees from universities around the world. David was Head of the Department of Chemistry and the Master of Downing College at the University of Cambridge. Over the course of his academic career, David has published over 500 papers on surface science and catalysis and on science and policy.

David was elected Fellow of the Royal Society in 1991 and was a Foreign Fellow of the American Academy of Arts and Sciences in 2002. He was knighted in 2003 and was made “Officier dans l’ordre national de la Légion d’Honeur” by the President of France in 2009.

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited, a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats such as Zika, Ebola, pandemic flu and antibiotic resistant bacteria.

It has developed a novel and ground-breaking approach to vaccine manufacturing, using 100% synthetic components to activate T-cells of the immune system to destroy virus-infected human cells. It uses unique technologies together with top-notch science to develop and manufacture vaccines much faster and at a fraction of the cost of traditional vaccines.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks. It also plans to develop commercially marketed vaccines in partnership with pharmaceutical companies to generate future licensing and royalty revenue streams.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Recently it joined the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

Media Contacts:

Instinctif Partners

Sue Charles /Ashley Tapp

Phone: +44 (0)20 7457 2020

Email: Emergex@instinctif.com

Emergex Builds its Finance Team with Two New Recruits

Oxford, UK, 28 March 2018 – Emergex Vaccines Holding Limited (‘Emergex’), a biotechnology company pioneering a new approach to vaccine development in the field of infectious diseases, today announces that it has built its Finance team and strengthening its operational capabilities.

Alex Bronimann joins Emergex as Finance Director. He brings over 20 years’ experience in the healthcare, pharmaceutical, technology, telecoms and manufacturing sectors. Alex’s strengths will contribute to financial strategy, focusing on financing activities, global costing, pricing and oversight of the Company’s finances. He leads day-to-day responsibility for financial controls and reporting, budgeting, forecasting, audit, tax, cash and treasury management.

Prior to Emergex, Alex was Finance Director at OrganOx Ltd, an Oxford University spin-out and start-up medical device company. Previously, Alex was Group CFO and Board Director at Adestra Group and before that he worked for several ‘blue chip’ companies including Vodafone, GE, Dell, Amersham and Cable & Wireless. Alex is a qualified Chartered Accountant.

Natalie Sands also joins Emergex’s new Finance function as Financial Controller. She is responsible for day-to-day financial operations including management reporting, payroll, supporting the audit process, and establishing robust financial policies and procedures.

Natalie has a broad range of experience in commercial finance including at large companies such as Live Nation Entertainment Ltd and Amey Plc. She joins Emergex from Amey Plc, where she was Senior Accountant within the Investments division, which included complex accounting for Special Purpose Vehicle Companies (SPV). Prior to this she was Group Financial Controller for Summit Therapeutics Plc. Natalie is a qualified Chartered Certified Accountant and is a Fellow member of the Association of Chartered Certified Accountants.

Professor Thomas Rademacher, co-founder, CEO and CSO at Emergex commented, “Alex and Natalie join Emergex at an exciting time in our growth as we look to advance the development of EMX-001, our universal Flavivirus vaccine candidate, for diseases such as Zika, Dengue and Yellow Fever towards clinical development early next year and our universal Filovirus and Influenza programmes in preclinical development. The new capabilities that Alex and Natalie bring will help support fundraising and ensure that we establish strong financial governance and cost controls as we grow.”

-Ends-

Notes to Editors

About Emergex Vaccines Holding Limited

Emergex Vaccines Holding Limited, a UK-based biotechnology company headquartered in Oxford, is pioneering a new approach to vaccine development in order to address some of the world’s most immediate health threats such as Zika, Ebola, pandemic flu and antibiotic resistant bacteria.

It has developed a novel and ground-breaking approach to vaccine manufacturing, using 100% synthetic components to activate T-cells of the immune system to destroy virus-infected human cells. It uses unique technologies together with top-notch science to develop and manufacture vaccines much faster and at a fraction of the cost of traditional vaccines.

Emergex is initially focussed on creating an internationally accessible, clinical grade vaccine repository for use by governments, non-governmental organisations and charities, to act as a first line of defence against existing and newly emerging infectious outbreaks. It also plans to develop commercially marketed vaccines in partnership with pharmaceutical companies to generate future licensing and royalty revenue streams.

Emergex is committed to making a positive impact in the communities that are most affected by these infectious outbreaks, where a lack of affordable and effective treatments adversely impacts health and prosperity. Recently it joined the Social Stock Exchange in London, the world’s first regulated exchange dedicated to businesses and investors seeking to achieve a positive social and environmental impact through their activities.

Find out more online at www.emergexvaccines.com.

Media Contacts:

Instinctif Partners
Sue Charles/ Ashley Tapp
Phone: +44 (0)20 7457 2020
Email: Emergex@instinctif.com